Esya
Esya For Alzheimer's

Cognitive Longevity For Neurodegenerative Diseases

Our mission is to monitor brain health and personalise therapeutic interventions. We combine patented intracellular multi-omics analytics using DNA nanoprobes and AI to diagnose neurodegenerative diseases before symptoms manifest.

Portrait of an older man

We Use Patented DNA Nanotechnology

A paradigm shift in understanding how Alzheimer's and Parkinson's diseases manifest opens up a whole new way of diagnosing, treating and managing the disease.

Our Probes

Quantitative Reporters For The Inside Of The Cell

Seven DNA-based probes, each reporting one chemistry from inside the organelle where it matters.

I-SwitchFRET-based pH sensor for the endo-lysosomal pathway and trans-Golgi networkpH
ClensorpH-independent ratiometric chloride sensor, single colour, multiplexing enabledChloride
CalipHluorRatiometric combination reporter of pH and calciumpH & Ca2+
Rhod-5F AzideRed-shifted calcium sensor, click-chemistry ready for conjugationCalcium
VoltairAbsolute membrane potential of cell and organelle membranesVoltage
NOckoutRatiometric nitric oxide probe for membranes, organelles and phagosomesNitric Oxide
ChloropHoreProprietary dual reporter of pH and chloride from the same locationpH & Cl
Our Assays

Accelerate Drug Development

Our ratio-metric assays are exceptional in their ability to quantify the key chemicals within endosomes (early, recycling, and late), lysosomes, and the golgi. They can be used to complement drug discovery and patient stratification, as well as assess drug efficacy as an end point in clinical trials for lysosomal storage disorders and numerous neurocognitive impairments.

Early endosomeQuantified
Recycling endosomeQuantified
Late endosomeQuantified
LysosomeQuantified
GolgiQuantified
Passion Is What Drives Us

Get In Touch To Discuss How Our Probes Can Help You With Your Work

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