A DNA-based pH sensor triggered by protons, based on fluorescence resonance energy transfer (FRET) inside living cells. It can work in vitro or target the endo-lysosomal pathway and trans-Golgi network in cultured cells or inside a living organism.
A fluorescent, pH-independent and ratiometric Cl− sensor, single colour and multiplexing enabled. Clensor can precisely measure the activity and location of subcellular chloride channels, targeting the endosome, lysosome and trans-Golgi network in vitro or in cellulo.
A DNA-based, ratiometric combination reporter of pH and Ca2+, measuring both from the same location so that organelles can be resolved by their chemical composition.
A red-shifted Ca2+ sensor that is click-chemistry ready, enabling easy conjugation with antibodies, proteins and other biomolecules. It can label the biomolecule of choice in vitro or in cellulo.
A pH-insensitive, DNA-based sensor for the absolute membrane potential of cell and organelle membranes. It can target the plasma membrane, endosome, lysosome and trans-Golgi network, in vitro and in cellulo.
A DNA-based ratiometric nitric oxide sensitive probe. It can target the plasma membrane, trans-Golgi network, endosome, lysosome or phagosome, and is applicable in vitro, intracellularly, in mouse microglia and in zebrafish brain.
Esya's proprietary DNA-based ratiometric combination reporter of pH and Cl−. It measures two ions simultaneously from the same location, allowing organelles to be resolved at high spatial resolution by their chemical composition.
